从Premna herbacea Roxbb中获得的阿比坦二烯酸及其生物活性
Passakorn Teerapongpisan1, Angkana Doungsanit2, Wuttichai Jaidee3
1Futuristic Science Research Center, School of Science, Walailak University, Nakhon Si Thammarat, 80160, Thailand; Research Center for Theoretical Simulation and Applied Research in Bioscience and Sensing, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
对Premna herbacea Roxb.的植物化学分析 根源产生了十种阿比二烯酸,包括五种新的化合物. 萨尔维伦显示出强大的α-葡萄糖酶抑制,而巴拉则对肺癌细胞表现出细胞毒性.
科学领域:
- 自然产品化学 自然产品化学
- 植物化学 植物化学
- 药用化学 医学化学
背景情况:
- 普雷姆纳草本植物 Roxb. 是一种具有潜在药用功能的植物.
- 亚比类型的二类是具有多种生物活动的自然产品的一类.
研究的目的:
- 从Premna herbacea Roxb.中分离和表征阿比类型的二甲. 一个根.根.根.
- 评估分离化合物的α-葡萄糖酶抑制和细胞毒性活动.
主要方法:
- 使用光谱分析 (1D和2DNMR,HRESIMS) 的植物化学调查.
- 电子循环二元化 (ECD) 计算用于结构确认.
- 在体外测定α-葡萄糖酶抑制和细胞毒性.
- 在基分子对接研究中.
主要成果:
- 隔离了十种阿比类型的二甲,包括五种新型化合物 (前纳尔比A和B,前纳尔比A-C).
- 萨尔维伦 (10) 显示出显著的α-葡萄糖酶抑制 (IC50 = 34.6 μM),超过了阿卡尔.
- 巴兰金 (2) 对A549肺腺癌细胞 (IC50 = 19.4μM) 具有显著的细胞毒性.
- 分子对接支持了萨尔维伦的抑制机制.
结论:
- 普雷姆纳草本植物 Roxb. 是一个丰富的结构多样化的阿维二烯酸的丰富来源.
- 萨尔维莱诺和巴拉显示出有前途的药理学活性,需要进一步调查.
- 为分离的化合物提出了一个合理的生物合成途径.
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