怀孕期间的多代吸烟和死产风险:基于人口的3代队列研究
Eduardo Villamor1, Amanda K Miglin1, Sven Cnattingius2
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
在怀孕期间,祖母吸烟会增加后代死产的风险. 即使考虑到共同的家族因素,也观察到这种跨代效应,突出显示了对胎儿生存的潜在表观遗传影响.
科学领域:
- 生殖流行病学 生殖流行病学
- 跨代人的健康影响
- 围产期结局的结果
背景情况:
- 怀孕期间母亲吸烟是已知的死产风险因素.
- 新出现的证据表明,吸烟对后代健康的潜在跨代影响.
- 祖母吸烟对孙子死产风险的具体作用尚未研究.
研究的目的:
- 调查祖母在怀孕早期吸烟与孙子死产风险之间的关联.
- 探索吸烟对胎儿生存的潜在跨代影响.
主要方法:
- 一项大规模的,三代瑞典队列研究,涉及祖母 (F0),母亲 (F1) 和孙子 (F2).
- 基于母亲祖母在怀孕第一季度的吸烟状况,对孙子孙女的死产风险进行比较.
- 利用母亲全身姐妹的吸烟状况作为负控制来解决由共同的家庭因素造成的未测量的混.
主要成果:
- 孙子死产的风险随着母亲祖母每天吸烟的香烟数量而增加.
- 调整后的相对风险为1.15 (1.01,1.31) 观察到任何祖母吸烟与不吸烟.
- 这种关联在男性后代中是显著的,并且与母亲吸烟有敌对的相互作用.
结论:
- 母亲祖母在怀孕早期吸烟与子孙死产的风险增加有关.
- 这种关联似乎独立于未测量的共同家族因素,表明潜在的非遗传遗传机制.
- 研究结果强调了在生殖健康研究中考虑代际影响的重要性.
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