胃肠癌的负担概况和可归因于死亡率的风险因素:综合分析,1990-2021年
Ahui Fan1, Chunbaixue Yang2, Yangyan Fan3
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
Journal of advanced research
|November 26, 2025
概括
胃肠道 (GI) 癌症在全球造成数百万人的死亡,东亚和老年男性不成比例地受到影响. 有针对性的公共卫生战略对于有效控制胃肠道癌症至关重要.
科学领域:
- 全球健康 全球健康
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 胃肠道 (GI) 癌症是一个重大的全球健康挑战,在全球范围内对癌症发病率和死亡率做出了重大贡献.
- 对胃肠道癌症负担和相关风险因素的全面了解对于制定有效的控制策略至关重要.
研究的目的:
- 为了确定高风险的地理区域和消化道癌症的人口.
- 为全球胃肠道癌症预防和控制提供有针对性的干预措施和基于证据的政策.
主要方法:
- 利用了2021年全球疾病负担研究 (GBD) 的数据,用于病例,残疾调整寿命年 (DALYs) 和年龄标准化率 (ASRs).
- 采用社会人口统计指数 (SDI) 来分类区域差异和Joinpoint回归来分析时间趋势.
- 使用比较风险评估框架计算风险因素贡献.
主要成果:
- 在2021年,胃肠道癌导致全球超过520万例病例,370万例死亡和8800万DALY.
- 东亚和高收入的亚太地区承担了全球肠道癌症负担的近一半;男性和65岁以上的个人受到了不成比例的影响.
- 结肠直肠和胃癌是主要的贡献者;烟草使用和高体重指数 (BMI) 被确定为各种肠胃癌类型的主要可修改的风险因素.
结论:
- 胃肠道癌症给全球带来了巨大而不均衡的负担,男性,老年人和东亚人群尤其容易受到影响.
- 风险因素模式的显著变化需要制定和实施针对性,区域特定的公共卫生干预措施,以控制肠道癌症.
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