血脂肪酸,遗传风险和发生的胰腺癌:一个前性队列研究
Wei Jiang1, Ji-Mei Gu2, Shu-Qi Mao1
1Department of Hepatopancreatobiliary Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
概括
较高的和脂肪酸 (SFAs) 摄入量会增加胰腺癌 (PC) 风险,而多不和脂肪酸 (PUFAs),特别是n-3 PUFAs,会降低癌症风险. 遗传风险可能会改变SFA效应,需要进一步研究.
科学领域:
- 营养流行病学 营养流行病学
- 癌症研究 癌症研究
- 遗传学 是一个遗传学.
背景情况:
- 关于脂肪酸 (FA) 含量和胰腺癌 (PC) 风险的证据有限.
- 遗传倾向在修改这种关联中的作用尚不清楚.
研究的目的:
- 调查循环脂肪酸 (SFAs,MUFAs,PUFAs) 与胰腺癌风险之间的关联.
- 检查PC的遗传风险对潜在效果的修改.
主要方法:
- 分析了一项大型英国生物银行队列研究 (249,165名参与者).
- 测量了血FA,并且考克斯回归模型评估了FA四分位数中的PC风险.
- 评估了FA与PC遗传风险之间的相互作用.
主要成果:
- 增加的和脂肪酸 (SFAs%) 与更高的PC风险有关 (HR 1.42).
- 多不和脂肪酸 (PUFA%),特别是n-3 PUFA%,与PC风险有相反的关联.
- 结合高SFA%和高遗传风险,显示PC风险显著增加 (HR 3.60).
结论:
- 血SFA升高与PC风险增加有关.
- 血PUFA,特别是n-3PUFA,与PC风险降低有关.
- SFAs与PC遗传风险之间的相互作用需要进一步调查.
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