长度功能变化及其对儿童癌症幸存者的长期影响:单中心回顾性队列研究
Itsuki Shimizu1, Ryo Nakatani2, Yugo Ito3
1Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.
Pediatrics and neonatology
|November 26, 2025
概括
儿童癌症幸存者 (CCS) 面临患慢性病 (CKD) 的高风险. 长期跟踪至关重要,因为功能下降甚至在CCS中暂时损伤恢复后也持续存在.
科学领域:
- 儿科瘤学 儿科瘤学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 癌症治疗的晚期影响
背景情况:
- 儿童癌症幸存者 (CCS) 患慢性病 (CKD) 的风险增加,这是治疗的晚期影响.
- 了解CCS中的纵向功能趋势对于管理长期健康至关重要.
研究的目的:
- 分析癌症治疗后的CCS中功能纵向趋势.
- 评估癌症治疗对儿科患者功能的长期影响.
主要方法:
- 135名儿童 (0-18岁) 接受癌症治疗 (2011-2021年) 的回顾性队列研究.
- 根据基于肌素 (eGFRcr) 的估计膜过率对正常功能 (≥90 mL/min/1.73 m2),功能不全 (RI),渐进性 RI 和过渡性 RI 分类的患者.
- 在诊断后的5年随访期间分析了纵向的eGFRcr趋势.
主要成果:
- 36%的CCS患有功能衰竭 (RI),其中20例是短暂的,29例是渐进的.
- 虽然正常和过渡性RI组在诊断后显示出eGFRcr的增加,但渐进性RI组显示出显著下降 (-12.2%).
- 与正常组相比,RI组在整个5年随访期间始终显示出较低的eGFRcr.
结论:
- 在CCS中观察到功能长期下降 (eGFRcr),即使在临时损伤后恢复过来.
- 这些发现强调了儿童癌症幸存者的功能持续长期监测的必要性.
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