β-葡萄糖预处理激活了莱克通路,以维持肠道Th17细胞的功能,以保护传染性肠炎
Yanbo Zhao1, Xiaochuan Mei1, Jin Yang1
1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Zoological research
|November 26, 2025
概括
贝塔葡萄糖 (BGs) 预处理通过增强莱克通路和调节Th17细胞反应来保护远鱼免受传染性肠炎的影响. 这突出了BG作为鱼类水产养殖的潜在战略.
科学领域:
- 免疫学 免疫学 免疫学
- 水生动物卫生 水生动物卫生
- 微生物学 微生物学
背景情况:
- 肠炎在肠道感染期间导致鱼类的免疫功能障碍.
- 免疫调节性β-葡萄糖 (BGs) 诱导训练免疫力,支持抗菌反应.
- 在保护远鱼免受传染性肠炎方面,BG预处理的作用基本上是未知的.
研究的目的:
- 在斑马鱼模型中研究BG预处理对传染性肠炎的保护作用.
- 阐明涉及莱克通路和免疫细胞调节的潜在机制.
主要方法:
- 使用Edwardsiella piscicida*感染建立了一个成年斑马鱼肠炎模型.
- 作为预处理的β-葡萄糖 (BGs) 的使用.
- 对促炎性细胞因子产生的分析.
- 评估肠道莱克通路的激活.
- 免疫细胞标记基因的综合RNA测序 (RNA-seq) 分析.
主要成果:
- 在斑马鱼中,BG预处理对斑马鱼的传染性肠炎给予了显著的保护.
- BG预治疗减少了促炎性细胞因子的产生.
- BG 预处理放大了与肠道莱克通路相关的补充激活.
- 莱克通路放大调节了肠道Th17细胞的反应,对保护至关重要.
结论:
- BG预处理通过增强乳素通路和调节Th17细胞反应来保护远鱼免受传染性肠炎的影响.
- 肠道莱克通路是培训免疫力中BG效应的关键调解者.
- 利用BG诱导的训练免疫力,为远鱼感染性肠炎提供了一个有前途的治疗策略.
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