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聚合酶甲基修复了在类切换重组过程中在S阶段持续的G1诱导的DNA断裂

Timea Marton1, Jinglong Wang2, Amaury Vaysse1,3

  • 1Institut Pasteur, Université Paris Cité, INSERM U1223, Équipe Labellisée Ligue Contre Le Cancer, Genome Integrity, Immunity and Cancer Unit, Paris, France.

Nature communications
|November 26, 2025
PubMed
概括

在B细胞中,免疫球蛋白类开关重组过程中的DNA双链断裂通过非同类末端连接 (NHEJ) 进行修复. 当NHEJ缺席时,聚合酶甲基 (Pol θ) 介导一种替代途径.

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