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Updated: Jun 22, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

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高效和长效的分裂和混合蛋白质溶解以自组装的聚乳酸为目标,以自组装的聚乳酸为基础

Mei-Miao Zhan1, Hailing Chen2, Meiling He2

  • 1Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, China.

Nature communications
|November 26, 2025
PubMed
概括

新的分裂和混合蛋白质分解降解 (SM-PROTAC) 技术使用聚乳酸 (PLA) 改善药物特性. 基于PLA的SM-PROTACs表现出增强的瘤抑制和较低剂量的长期治疗潜力.

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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