认知障碍中明显的脑部变化和神经退行过程与COVID-19后急性后果相关
Dayoung Seo1,2, Yangsean Choi3, Eunseon Jeong2,3
1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Nature communications
|November 26, 2025
概括
COVID-19 (Cog-PASC) 后的认知障碍与大脑变化和神经退行症标志物有关. 这些明显的脑部变化表明Cog-PASC患者的特定神经退行过程.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- SARS-CoV-2 (PASC) 后急性后续可能涉及神经系统症状.
- 在PASC中报告了大脑变化,但它们与神经退行症的联系尚不清楚.
研究的目的:
- 调查COVID-19后认知障碍 (Cog-PASC) 患者的脑部变化和血液蛋白质变化.
- 确定这些变化是否与神经退行相关,并且与其他PASC亚型不同.
主要方法:
- 血液蛋白质组学和大脑MRI分析在轻度COVID-19后1年的人身上.
- 在Cog-PASC,其他PASC (非认知障碍) 和非PASC对照组之间进行比较.
- 使用探索,共变量匹配和独立验证队列.
主要成果:
- Cog-PASC组在血液中显示出高质和神经元损伤标志物.
- 在Cog-PASC中,大脑MRI揭示了皮质稀薄 (状,岛状),海马敏感度增加,以及状缩.
- 血液蛋白质学表明,在Cog-PASC中,与神经退行相关的氧化应激和突触功能改变.
结论:
- 轻度的COVID-19可能会导致认知障碍 (Cog-PASC) 患者的明显神经退行过程.
- 观察到的大脑变化和蛋白质变化可以在队列中复制.
- 这些发现将Cog-PASC与其他PASC呈现区分开来,突出了特定的神经系统序列.
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