孤独轨迹与慢性阻塞性肺病的关联,来自中国的队列研究
Zhishen Ruan1, Dan Li2, Bo Xu1
1Xiyuan Hospital of Chinese Academy of Chinese Medical Sciences, Beijing, China.
孤独的轨迹,特别是持续高或不断增加的水平,显著提高患慢性阻塞性肺病 (COPD) 的风险. 这突显了心理社会因素在呼吸系统健康中的关键作用.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理社会医学 心理社会医学
背景情况:
- 孤独和慢性阻塞性肺病 (COPD) 之间的关系需要进一步研究.
- 了解孤独的动态对于评估COPD风险至关重要.
研究的目的:
- 检查孤独与COPD发病率之间的关联.
- 分析不同孤独轨迹对COPD发展的影响.
主要方法:
- 利用来自中国健康与退休长度研究 (CHARLS) 的数据,其中8006名参与者年龄≥45.6岁.
- 采用基于群体的轨迹建模 (GBTM) 来识别随时间推移的孤独模式 (2011-2018).
- 应用COX比例风险回归来评估与孤独相关的COPD发病率风险.
主要成果:
- 确定了三个孤独轨迹:持续低 (76.14%),持续高 (10.60%),以及增加 (13.26%).
- 持续高的 (HR=1.66) 和增加的孤独 (HR=1.65) 轨迹与更高的COPD风险有显著的关联.
- 基线孤独也增加了24%的COPD风险.
结论:
- 孤独,尤其是持续或不断升级的孤独,是发展COPD的重要危险因素.
- 孤独等心理社会因素在慢性呼吸道疾病的发病过程中起着至关重要的作用.
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