Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antimicrobial Proteins01:23

Antimicrobial Proteins

12.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.9K
Amino Acid Catabolism01:18

Amino Acid Catabolism

954
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
954
Types of RNA01:23

Types of RNA

72.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.4K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

479
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
479
The Electron Transport Chain01:30

The Electron Transport Chain

19.6K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
19.6K
Stringent Response in E. coli01:23

Stringent Response in E. coli

272
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
272

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization.

bioRxiv : the preprint server for biology·2026
Same author

Peroxisomes orchestrate metabolic flexibility and longevity via an interorganelle cascade.

Nature aging·2026
Same author

Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation.

Nature immunology·2026
Same author

Bacterial pyruvate metabolism regulates host insulin sensitivity in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2026
Same author

A Polymeric Nanocarrier Platform for Rapid and Precise Fatty Acid Tracing in Cells.

ACS applied bio materials·2025
Same author

Dietary restriction reprograms CD8<sup>+</sup> T cell fate to enhance anti-tumour immunity and immunotherapy responses.

Nature metabolism·2025

相关实验视频

Updated: Jan 10, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.7K

来自细菌的非正规聚胺对抗宿主线粒体功能.

Kelsie M Nauta1, Darrick R Gates1, Matthew Weiland1

  • 1Van Andel Research Institute, Department of Metabolism and Nutritional Programing, Grand Rapids, MI, USA.

Nature communications
|November 26, 2025
PubMed
概括

肠道细菌可以产生一种新型的多胺,N1-aminopropylagmatine (N1-APA),它破坏肠道细胞功能,并可能通过影响线粒体应激反应,导致炎症性肠道疾病.

更多相关视频

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

13.0K
Author Spotlight: Advancing Caenorhabditis elegans Research Using Paraformaldehyde-Treated Bacteria
06:58

Author Spotlight: Advancing Caenorhabditis elegans Research Using Paraformaldehyde-Treated Bacteria

Published on: July 28, 2023

3.1K

相关实验视频

Last Updated: Jan 10, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.7K
Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

13.0K
Author Spotlight: Advancing Caenorhabditis elegans Research Using Paraformaldehyde-Treated Bacteria
06:58

Author Spotlight: Advancing Caenorhabditis elegans Research Using Paraformaldehyde-Treated Bacteria

Published on: July 28, 2023

3.1K

科学领域:

  • 微生物学 微生物学
  • 分子生物学分子生物学
  • 毒理学 毒理学 毒理学

背景情况:

  • 肠道细菌聚胺与肠道细胞相互作用,可能影响炎症性肠道疾病 (IBD).
  • 关联肠道微生物组聚胺代谢与IBD病变的分子机制在很大程度上仍未被定义.

研究的目的:

  • 通过使用模型生物体,研究微生物组衍生的多氨酸的生物活性.
  • 在肠道细胞中阐明聚胺中间体N1-aminopropylagmatine (N1-APA) 的分子机制.

主要方法:

  • 使用基于衍生性的液态色谱-质谱法 (LC-MS).
  • 采用了模型生物Caenorhabditis elegans和小鼠骨髓巨细胞.
  • 通过CATP-5传送器进行研究的聚胺运输.

主要成果:

  • 确定了N1-aminopropylagmatine (N1-APA) 作为由大肠杆菌和细菌细菌产生的一种非正规的聚胺中间体.
  • 在C. elegans中表现出N1-APA生物活性,对抗发育并激活线粒体展开的蛋白质反应.
  • 显示的N1-APA抑制了eIF5A的低化和替代性巨细胞激活,类似于脱氧基素合成酶抑制剂.

结论:

  • 细菌N1-APA是一种具有潜在作用于线粒体应激反应的生物活性代谢物.
  • 异常的肠道微生物组聚胺代谢,导致N1-APA的产生,可能有助于IBD的发病.
  • 需要进一步的研究来确定N1-APA的所有点及其在疾病中的确切作用.