在诊断具有临床意义的门门高血压时,低波辅助压力估计的预测值
Yoshiko Nakamura1, Masashi Hirooka2, Ryo Yano1
1Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 454 Toon, Ehime, 791-0295, Japan.
Scientific reports
|November 26, 2025
概括
修订后的超声波辅助压力估计 (SHAPE) 方法使用超声波准确预测临床显著的门高血压 (CSPH). 这种非侵入性技术为评估肝病严重程度的侵入性测量提供了一个有希望的替代方案.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 超声波技术 超声波技术 超声波技术
背景情况:
- 门性高血压 (PH) 是慢性肝病的一种严重并发症.
- 目前临床显著PH (CSPH) 的诊断方法通常涉及侵入性程序,如肝静脉压梯度 (HVPG) 测量.
- 需要准确的,非侵入性的方法来评估PH的严重程度.
研究的目的:
- 评估经过修订的超声波辅助压力估计 (SHAPE) 方法的诊断性能,用于识别CSPH.
- 将SHAPE的预测准确度与现有的非侵入性标记物和侵入性HVPG测量进行比较.
主要方法:
- 一项涉及62名慢性肝病患者的横截面研究.
- 患者接受了HVPG,肝硬,硬 (SSM) 和SHAPE测量.
- 确定SHAPE的截止值以预测CSPH (HVPG≥10 mmHg).
主要成果:
- SHAPE梯度与HVPG有很强的相关性 (r=0.74,p<0.01).
- 与没有CSPH的患者相比,CSPH患者的SHAPE梯度显著更高.
- 最佳的SHAPE截止值为-2.7dB,显示出高灵敏度 (92%),特异性 (87%) 和AUC为0.94的CSPH预测,优于其他非侵入性方法.
结论:
- 修订后的SHAPE方法是评估HVPG的高度准确,非侵入性工具.
- 在临床实践中,SHAPE显示出作为CSPH诊断替代品的巨大潜力.
- 这种基于超声波的方法可能会减少对治疗肝病的侵入性手术的需要.
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