双相情感障碍中LNCRNAs的LINC03091和LINC03090的改变表达:一个病例控制研究
Zeynab Ganji Zeitooni1, Zeinab Shirvani-Farsani2, Bahar Naghavi Gargari3,4
1Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IR, Iran.
Scientific reports
|November 26, 2025
概括
这项研究发现双相情感障碍 (BD) 患者中LINC03091和LINC03090长非编码RNA (lncRNAs) 的水平升高. 这些lncRNAs显示出作为BD的诊断生物标志物的潜力.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
背景情况:
- 长非编码RNAs (lncRNAs) 是基因表达的关键调节者.
- 失调的lncRNAs与精神疾病有关,包括双相情感障碍 (BD).
- 了解IncRNA在BD病变发生中的作用对于开发诊断工具至关重要.
研究的目的:
- 为了研究两极性障碍中LRRC2-AS1,LINC03091和LINC03090 lncRNAs的表达水平.
- 评估这些lncRNAs作为BD诊断生物标志物的潜力.
主要方法:
- 分析了50名BD患者和50名健康对照的血液样本中的IncRNA表达.
- 使用实时聚合酶连锁反应进行量化.
- 通过接受器操作特征 (ROC) 曲线分析评估生物标志物潜力.
主要成果:
- 与对照组相比,在BD患者中,LINC03091 (P < 0.0001) 和LINC03090 (P = 0.02) 的表达显著增加.
- LRRC2-AS1表达没有显著差异 (P = 0.69).
- ROC分析证实LINC03091 (AUC = 0.74) 和LINC03090 (AUC = 0.64) 是BD患者和健康个体之间的有效区分.
结论:
- 在双相情感障碍患者中,LINC03091和LINC03090的高调显著.
- 这些lncRNAs显示出作为BD诊断和预测的有价值生物标志物的潜力.
- 进一步研究它们在BD病原发生中的功能作用是有必要的.
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