在超临界CO2中测量和建模瑞扎特里普坦,用于制药加工
1Department of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. sbawazeer@uqu.edu.sa.
Scientific reports
|November 26, 2025
概括
这项研究研究了瑞萨特里普坦在超临界二氧化碳中的溶解性,用于环保药物制造. 索迪夫人和其他人. 模型 (II) 和常规溶液模型与实验数据有很好的一致性.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 超临界二氧化碳 (scCO2) 为药物制造提供了一个环保的替代方案.
- 利扎特里普坦是偏头痛的关键药物,需要高效和可持续的生产方法.
研究的目的:
- 为了确定瑞扎特里普坦在超临界二氧化碳中的可溶性.
- 评估和比较各种热力学模型来预测可溶性.
- 支持在制药生产中开发绿色化学方法.
主要方法:
- 在scCO2中测量了瑞扎特里普坦在308.2338.2K的温度范围和1230MPa的压力范围内的可溶性.
- 七个基于密度的模型 (克拉斯蒂尔,巴特尔,库马尔-约翰斯顿,门德兹-圣地亚哥-特哈,比安等人,索迪菲安等人. I和II) 应用于可溶性数据.
- 还检查了三个热力学方程 ( - 罗宾逊,索瓦 - 雷德利希 - 克旺,正则解).
主要成果:
- 里扎特里普坦在scCO2中的溶解度从0.24 × 10−4到4.19 × 10−4摩尔分数不等.
- 索迪夫人和其他人. 模型 (II) 显示出高精度 (AARD = 7.78%,R2 = 0.990),而常规溶液模型表现最好 (AARD = 6.89%,R2 = 0.991).
- 确定了热力学指标,包括溶解的度.
结论:
- 这项研究提供了瑞扎特里普坦在scCO2中的关键可溶性数据.
- 经过验证的模型可以提高超临界流体技术,以实现更绿色的制药制造.
- 这项研究有助于制定可持续的药物生产战略.
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