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Updated: Jan 6, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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通过在骨质母细胞中激活PI3K/AKT/mTOR通路,抑制GCNT2促进了骨质母细胞的分化

Yansheng Huang1, Sibo Wang1, Dong Hu2

  • 1Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, Shaanxi, China.

Scientific reports
|November 26, 2025
PubMed
概括

葡萄糖胺基 (N-乙) 转移酶2 (GCNT2) 基因倒置通过激活PI3K/AKT/mTOR通路,促进骨质疏松症中的骨质细胞分化. 这表明GCNT2抑制是骨质疏松症治疗的潜在治疗策略.

关键词:
在 GCNT2 中.骨质母细胞分化差异化骨质疏松症是一种骨质疏松症.在PI3K/AKT/mTOR中使用.

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