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Updated: Jan 10, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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组合疗法克服了ATM缺陷前列腺癌中的二次PARPi抵抗

Sara Arce-Gallego1, Victor Esquefa1, Heura Domenech2,3

  • 1Prostate Cancer Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.

NPJ precision oncology
|November 26, 2025
PubMed
概括

PARP 抑制剂 (PARPi) 对转移性前列腺癌 (mPC) 具有 HRR 缺陷的治疗有希望. 将PARPi与ATR抑制剂 (ATRi) 结合使用可以通过增强复制应激来克服耐药性,从而改善患者的治疗结果.

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