德克斯梅德托米丁作为NICU的主要镇静剂
Alexandra Caballero1, Ferras Bashqoy2, Maria Spilios1
1Department of Pharmacy, Hassenfeld Children's Hospital at NYU Langone Health, New York, NY, USA.
概括
德克斯梅德托米丁是一种安全有效的新生儿初级镇静剂,显著减少了对阿片类药物和二胺类药物的需求. 这种方法还可以帮助新生儿更快地获得全.
科学领域:
- 新生儿重症监护室新生儿重症监护室
- 儿科药理学 儿科药理学
- 镇静剂和镇痛剂的使用.
背景情况:
- 新生儿镇静通常依赖于阿片类药物和二.
- 有关这些药物对新生儿的长期影响存在担忧.
- 需要使用替代性镇静剂,以尽量减少对传统药物的暴露.
研究的目的:
- 评估德克斯梅德托米丁作为新生儿初级镇静剂的安全性和有效性.
- 为了比较德克斯梅德托米丁与阿片类药物/二氨酸在机械通风新生儿的镇静作用.
- 评估德克斯梅德托米丁对阿片类药物/二胺类药物需求和临床结果的影响.
主要方法:
- 追溯性,单中心研究,比较德克斯梅德托米丁 (研究组) 与阿片类药物/二类药物 (对照组).
- 包括148名机械通风的新生儿.
- 主要结局:阿片类药物/二二类药物需求;次要结局:通风持续时间,充分食的时间,心肌梗塞/低血压,无计划的输出.
主要成果:
- 与对照组 (n=57) 相比,德克斯梅德托米丁组 (n=91) 的累积阿片类药物/二甲类药物暴露显著减少.
- 在德克斯梅托米丁组中,中位数的阿片类药物/二胺剂需求量为0 mg/kg/天.
- 德克斯梅德米丁组更快地达到充分养;无计划的输出管在两组之间是相似的.
结论:
- 德克斯梅德托米丁作为新生儿的主要镇静剂是安全有效的.
- 它显著降低了对阿片类药物和二类药物的需求,无论是在期限和早产新生儿.
- 有助于更快地实现完整的肠道食.
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