自然产品作为炎症媒介癌症的治疗干预措施
Srabaita Roy1,2, Ranjit Shaw1,3, Akanksha Pandey1
1Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Discover oncology
|November 26, 2025
概括
炎症在癌症中起着双重作用,有助于瘤的发展和进展. 本综述探讨了由癌症引起的炎症 (CEI) 和调节这些通路的自然产品.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 炎症是一个关键的免疫反应,但慢性炎症驱动癌症的发展 (炎症诱导的瘤发生).
- 癌症引起的炎症 (CEI) 发生在瘤开始后,与瘤形成之前的炎症不同.
- 瘤基因激活 (例如KRAS,MYC) 和瘤抑制剂无活化 (例如TP53) 通过细胞因子和血管生成促进了亲瘤微环境.
研究的目的:
- 综合审查由癌症影响的炎症途径及其在癌症进展中的作用.
- 研究天然产品对抗炎症和抗癌作用的机制.
主要方法:
- 文献综述侧重于炎症在癌症中的作用.
- 对癌症引起的炎症背后的分子机制的分析.
- 探索天然产品对炎症和癌症途径的调节作用.
主要成果:
- 癌症积极操纵炎症路径以促进其生长和传播.
- CEI涉及转录程序,导致细胞因子的过度生产,免疫细胞的招募和血管生成.
- 特定的自然产品在调节这些复杂的分子通路方面表现出潜力.
结论:
- 了解CEI对于开发有效的癌症治疗和预防策略至关重要.
- 天然产品在癌症治疗中为调节炎症提供了有希望的途径.
- 对CEI和天然产品机制的进一步研究可能会导致新的治疗干预措施.
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