视网膜微血管和心血管结局的断层分析:系统性审查和元分析
Yihao Lian1,2, Guixin Li1,3, Haoyu Liu4
1Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
BMC ophthalmology
|November 27, 2025
概括
视网膜血管碎片尺寸 (FD) 的降低与较高的心血管疾病 (CVD) 风险有关,特别是在动脉小管中. 这一发现表明FD可能是早期心血管疾病查的有价值的非侵入性标记.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 医疗成像医学成像
背景情况:
- 心血管疾病 (CVD) 构成了全球严重的健康负担.
- 视网膜微血管结构的改变可能反映系统性血管变化.
- 分形维度 (FD) 量化了血管网络的复杂性.
研究的目的:
- 系统地审查和综合有关视网膜血管碎片维度 (FD) 和心血管疾病 (CVD) 风险之间的相关证据.
- 调查FD是否可以作为CVD发展的预测生物标志物.
主要方法:
- 一个系统的审查和对队列和横截面研究的元分析.
- 在PubMed,科学网和柯克兰图书馆数据库中进行的搜索,截至2025年6月.
- 用于组合风险估计的随机效应模型;执行子组和灵敏度分析.
主要成果:
- 包括14项研究 (8个队列,6个截面) 在内.
- 连续性和分类性FD降低与心血管疾病发病率增加显著相关 (RR分别为1.14和1.51).
- 减少的FD与已确定的心血管疾病 (RR: 1.70) 相关,特别是动脉动脉FD (RR: 1.08-1.90),但不是静脉FD.
结论:
- 视网膜微血管FD,特别是动脉FD,是心血管疾病风险的重要指标.
- 飞行器的测量显示了作为CVD风险分层和早期检测的非侵入性辅助的潜力.
- 这些发现支持FD在识别患中风和冠心病等疾病风险较高的个体方面的作用.
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