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人类乳头瘤病毒精液载体改变病毒组多样性和男性生育能力:一个病例控制研究

Elissa Kansou^1,2, Aurélien Aubry^1,2, Etienne Brochot^1,2

¹Virology Department, Amiens University Medical Center, Amiens, F-80000, CEDEX 1, France.

Reproductive biology and endocrinology : RB&E

|November 27, 2025

概括

人类乳头瘤病毒 (HPV) 感染男性可能会改变精子病毒组,可能会影响精子参数和男性生育能力. 需要进一步的研究来了解这些复杂的病毒相互作用及其对生殖健康的影响.

科学领域:

生殖生物学生殖生物学
病毒学病毒学
生殖和泌尿系统医学

背景情况:

异形性男性不孕症越来越多地与精液中的病毒感染有关.
人类乳头瘤病毒 (HPV) 是全球普遍存在的性传播感染.
HPV 对男性生殖器病毒的影响及其与生育能力的关联是不充分研究的.

研究的目的:

为了研究男性有或没有HPV感染的男性精液病毒组合.
为了比较HPV阳性和HPV阴性不育男性之间的精子病毒组特征和精子参数.

主要方法:

对28名参加生育诊所的男性 (15例HPV阳性病例,13例HPV阴性对照) 的回顾性研究.
下一代元基因组测序用于分析精子样本中的分子病毒组.
病例和对照之间的基因组,临床和精子相关特征的比较.

主要成果:

在HPV阳性病例的精液病毒组中,Papillomaviridae占主导地位.
与对照人群相比,Herpesviridae,Polyomaviridae和其他病毒序列在病例中较少.
两组之间没有观察到总体病毒多样性的显著差异,但病毒多样性与HPV阳性男性的精子参数相关.

结论:

男性的精子病毒组主要由帕皮洛马病毒,赫尔佩斯病毒和多聚马病毒组成.
精子病毒组内的HPV特异性相互作用可能会影响受感染个体的精子参数.
精子病毒组的变化,特别是由于HPV,可能会对男性生育能力产生负面影响.

关键词:

高通量测序的高通量测序人类乳头瘤病毒人类乳头瘤病毒男人不孕不育的情况转基因组学是什么意思?精子精子精子病毒组病毒组病毒组

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