合成重新设计的Corynebacterium glutamicum通过L-谷氨酸衍生的CoA独立路径生产1,4-butanediol

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Jinyoung Kim1, Hyeon Jin Kim2, Sukjae Han2

  • 1School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, South Korea.

Journal of biological engineering
|November 27, 2025
PubMed
概括

使用Corynebacterium glutamicum开发了一个新的微生物平台,用于从葡萄糖中生产1,4-butanediol (1,4-BDO). 这种工程菌株通过优化生物合成途径并消除产品降解,实现了13,4g/L的1,4-BDO.

关键词:
在Corynebacterium glutamicum的研究中,我们发现1,4-丁二醇的使用方法代谢工程是代谢工程.通过RNA-seq分析进行分析.

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