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Updated: May 5, 2026

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塞法林诱导的凝血病:一个病例报告

Olivier Zerbib1, Daniel Kovarsky2, Michael Oshrov3

  • 1Depatement of General Intensive Care, Rabin Medical Center, Hasharon Hospital, Keren Kayemet Street, 49100, Petah Tikva, Israel. Zerbib.oliv@gmail.com.

Journal of medical case reports
|November 27, 2025
PubMed
概括

塞法林诱导的凝血病是治疗塞法林的罕见但严重的不良反应. 及时识别和维生素K的管理对于管理这种并发症至关重要,这种并发症可以随着或没有出血而发生.

关键词:
抗生素 抗生素是一种抗生素.这是一种Cefazolin.凝血障碍是一种凝血障碍.与药物相关的副作用和不良反应血液学疾病 血液学疾病发生出血并发症.

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Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These...
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