在有代谢功能障碍的个体中,脂蛋白,肝脏和血管损伤之间的相互作用
Serena Pelusi1, Chiara Macchi2, Francesco Malvestiti3
1Transfusion Medicine and Precision Medicine - Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Marangoni Pavilion, Via F Sforza 35, 20122, Milan, Italy.
肝损伤,而不是遗传倾向,可能会降低血脂蛋白[Lp[a]水平. 测量Lp(a) 和肝损伤可以改善血管风险预测.
科学领域:
- 心血管医学 心血管医学
- 肝病学 肝病学是一种肝病学.
- 遗传学 遗传学 是一个
背景情况:
- 血脂蛋白 (Lp) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的相互作用尚不清楚.
- 研究Lp(a) 和MASLD对肝脏和血管健康的联合影响至关重要.
研究的目的:
- 探索Lp(a) 水平和MASLD.之间的关系.
- 确定Lp (a) 对具有代谢功能障碍的个体肝脏和血管损伤的影响.
主要方法:
- 使用了肝-圣经队列 (n=859) 和米兰生物银行 (n=6963).
- 采用全基因组关联研究 (GWAS) 和多基因风险评分 (PRS) 来分析影响Lp的遗传因素.
- 评估肝硬度测量 (LSM) 和大脑动脉样硬化斑块.
主要成果:
- LPA基因的遗传变异强烈影响了Lp (a) 水平,肝硬度测量 (LSM) 也发挥了作用.
- 循环中的Lp(a) 水平,但不是遗传因素,显示与LSM的反向关系,这表明MASLD的严重程度会影响Lp(a) 分泌.
- 在患有严重胰岛素耐药性的参与者中,高的Lp (a) 和LSM与传统风险因素无关的动脉斑块患病率增加有关.
结论:
- 肝损伤似乎是血Lp (a) 水平降低的原因,而不是后果.
- 血Lp (a) 和肝损伤程度的综合评估可以提高血管损伤的预测.
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