系统性炎症指数调解了肠道微生物群的饮食摄入量和肌肉质量之间的关联:一个横截面研究
Yuyang Shi1,2, Huiqiao Zhou3, Qihui Fu1
1Jiangxi Medicine Academy of Nutrition and Health Management, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Nutrition & metabolism
|November 27, 2025
概括
促进健康肠道微生物群的饮食与增加肌肉质量有关. 系统性炎症部分调解了这种积极的关联,这表明饮食干预可能有助于预防肌肉损失.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 老年学是一门学科.
背景情况:
- 肠道微生物群与健康饮食和肌肉质量之间的关系尚未得到充分理解.
- 系统性炎症在这种关系中的潜在调解作用需要进一步研究.
研究的目的:
- 研究肠道微生物群的饮食指数 (DI-GM) 与肌肉质量 (骨肌肉质量指数,SMI) 之间的关联.
- 探索系统性炎症指数 (SII) 在DI-GM和SMI关联中的调解作用.
主要方法:
- 在6908名成年人 (20-59岁) 的横截面研究中,使用了国家健康和营养检查调查数据 (2010-2018).
- 从13个饮食成分计算DI-GM;使用尾瘦质量和身高评估SMI.
- 从血小板,中性粒细胞和淋巴细胞计数计算SII;进行了多变量线性回归和中介分析.
主要成果:
- 更高的DI-GM得分与SMI的增加显著相关 (β=0.03;95% CI:0.01至0.04).
- 这种关联在不饮酒者中更强.
- SII部分调解了DI-GM-SMI协会,占影响的11.6%.
结论:
- 支持健康肠道微生物群的饮食与肌肉质量有积极的关联.
- 系统性炎症在这种关联中起着部分调解作用.
- 针对肠道微生物群的饮食策略可能有助于通过调节炎症来保持肌肉质量.
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