乙二酸对冠心病的影响:全面的计算分析
Xu Ma1, Yingying Liu2, Zhen Hua2
1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, China.
BMC pharmacology & toxicology
|November 27, 2025
概括
乙支柱酸盐 (ATBC) 暴露可能会增加冠心病 (CHD) 的风险. 这项研究确定了MMP9,NLRP3和PLAU作为参与ATBC诱导的CHD病原发生的关键基因,提供了潜在的治疗点.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 心血管研究研究心血管研究
背景情况:
- 新出现的证据将乙三酸 (ATBC) 暴露与冠状动脉心脏病 (CHD) 的风险增加联系起来.
- 了解ATBC在心血管疾病中的作用的分子基础对于公共卫生至关重要.
- 这项研究解决了阐明ATBC可能导致心血管疾病的机制的需要.
研究的目的:
- 调查通过支酸 (ATBC) 可能有助于冠状动脉心脏病 (CHD) 病变的分子机制.
- 确定关键的分子标和涉及ATBC诱导心血管风险的途径.
- 为了验证ATBC与已识别的目标基因的结合亲缘关系.
主要方法:
- 使用ChEMBL和SwissTargetPrediction数据库来识别ATBC目标.
- 进行功能性丰富分析和基因组丰富分析 (GSEA) 以探索致病机制.
- 使用机器学习算法 (例如,随机森林) 和ROC曲线来识别诊断模型和关键枢纽基因 (MMP9,NLRP3,PLAU).
- 使用单细胞转录组数据和分子对接来评估ATBC与枢纽标的结合亲缘关系的验证结果.
主要成果:
- 确定了与ATBC诱导的CHD相关的关键枢纽基因 (MMP9,NLRP3,PLAU),与代谢障碍,雌激素抵抗和血管炎症有关.
- NLRP3在单细胞中表达占主导地位,而PLAU在纤维细胞和内皮细胞中表达高.
- 分子对接证实了ATBC和MMP9/PLAU之间显著的结合亲缘关系,支持它们在CHD病变发生中的作用.
结论:
- 乙支柱酸盐 (ATBC) 可能通过涉及MMP9,NLRP3和PLAU的已识别的分子机制促进心血管疾病的进展.
- 这些枢纽基因代表了未来研究ATBC相关心血管风险的新型分子标.
- 这些发现强调了ATBC暴露在常见应用中的潜在健康影响.
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