骨关节炎患者的饮食维生素E摄入量和全因死亡率:使用NHANES数据的前性队列研究
Fan Yang1, Yongqing Liu2, Weihua Sang2
1Department of Orthopedic, CangZhou Central Hospital, CangZhou, Hebei, 061000, PR China. dryang1992@163.com.
European journal of medical research
|November 27, 2025
概括
较高的饮食维生素E摄入量与骨关节炎患者的死亡风险降低有关. 最佳摄入量似乎在8.55毫克/天左右,在这个水平以上,益处会减少.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 饮食维生素E在骨关节炎 (OA) 进展中的作用正在调查中.
- 它对关节炎患者死亡风险的影响尚不清楚.
- 这项研究研究了饮食维生素E与美国OA成年人全因死亡率之间的关联.
研究的目的:
- 研究美国成年人诊断患有骨关节炎的饮食维生素E摄入量和全因死亡率之间的关系.
- 探索潜在的非线性剂量反应关系,并确定各个子组的死亡风险变化.
主要方法:
- 对2,974名美国OA成人的横截面分析 (2003-2018年NHANES数据).
- 与国家死亡指数相关的死亡率数据,追踪到2019年12月.
- 使用了考克斯的比例危险模型和受限立方线分析.
主要成果:
- 较高的饮食维生素E摄入量与OA患者的全因死亡率有显著的反向关联 (P < 0.001).
- 观察到非线性关系,值效应为8.554毫克/天.
- 摄入量低于8.55毫克/天显著降低了死亡风险;在这个值以上没有发现显著的相关性.
结论:
- 在OA患者的饮食维生素E摄入量和死亡率之间存在非线性反向关联,值为8.55毫克/天.
- 低于值的维生素E摄入量显著降低了死亡风险,这表明对OA营养管理的影响.
- 需要进一步的前性研究来确定因果关系.
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