接种COVID-19疫苗后中风的发生率:卡塔尔全国自控风险间隔研究
Hiam Chemaitelly1,2, Naveed Akhtar3, Salman Al Jerdi3,4
1Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
Expert review of vaccines
|November 27, 2025
概括
接种COVID-19疫苗显示,在21天内,中风风险略微暂时增加. 然而,这些中风事件仍然非常罕见,风险低于感染.
科学领域:
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 在COVID-19疫苗接种后评估短期中风风险对公共卫生至关重要.
- 卡塔尔的国家卫生数据为这项调查提供了一个强大的平台.
研究的目的:
- 评估COVID-19疫苗接种与短期中风风险之间的关联.
- 量化疫苗接种后中风发病率的任何潜在增加.
主要方法:
- 采用了一种自我控制的风险间隔研究设计.
- 与对照窗口 (43-180天) 相比,在接种疫苗后的特定时间窗口 (0-21天,22-42天) 中分析了中风病例.
- 数据来源于卡塔尔国家中风注册和健康平台.
主要成果:
- 在接种疫苗后的0-21天窗口中观察到较高的中风发病率 (IRR: 1.32).
- 在22-42天窗口中没有发现中风风险的显著增加 (IRR:1.03).
- 估计的超额风险为每10万剂疫苗中0.55次中风,具体发现是BNT162b2和mRNA-1273疫苗以及中风亚型.
结论:
- 在COVID-19疫苗接种后21天内,中风发病率的轻微暂时上升发生.
- 接种疫苗后中风的总体风险非常低.
- 这种与疫苗相关的风险远低于与COVID-19感染相关的中风风险.
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