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Updated: Jan 10, 2026

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骨关节炎和冠状细胞:从机制到治疗的道路上

J T Huh1, A Zheng1, B Kheyfets1

  • 1Cartilage Biology and Regenerative Medicine Laboratory, Section of Growth and Development, Division of Orthodontics, College of Dental Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Journal of dental research
|November 27, 2025
PubMed
概括

骨关节炎 (OA) 涉及细胞,它们积极推动关节的降解. 向Wnt通路显示出通过稳定软骨的新型疾病修饰性OA药物 (DMOADs) 的前景.

关键词:
没有信号发送.软骨 软骨 软骨是一种改变疾病的骨关节炎药物 (DMOADs)骨关节炎动物模型关节 (TMJ) 是一个关节.

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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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