维生素D缺乏的纠正改善了海湾战争退伍军人的PTSD症状
Chandrasekhar Kesavan1,2,3, Donna D Strong3, Richard M Strong1,2
1Department of Gastroenterology, VA Loma Linda Healthcare System, Loma Linda, CA 92357, USA.
Brain sciences
|November 27, 2025
概括
患有IBS-D的海湾战争退伍军人经常患有PTSD或TBI. 纠正维生素D缺乏 (VDD) 在这些退伍军人中改善了抑郁症,焦虑症,PTSD和TBI的症状.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 湾岸战争退伍军人 (GWV) 患有易怒肠综合征-腹 (IBS-D) 经常出现同时发生的创伤后应激障碍 (PTSD) 或创伤性脑损伤 (TBI).
- 之前的研究表明,GWV患有IBS-D的患者有显著的维生素D缺乏 (VDD),不论是并发性PTSD或TBI.
- 视觉障碍被认为是导致创伤后应激障碍的潜在因素,这促使人们对其在患有这些疾病的GWV中所扮演的角色进行调查.
研究的目的:
- 调查VDD与神经心理疾病 (PTSD,TBI) 之间的关联,在出现IBS-D的GWV患者中.
- 确定纠正VDD对这种退伍军人群体心理症状的影响.
主要方法:
- 一组患有IBS-D的GWV,包括患有PTSD和/或TBI的人,被评估VDD.
- 分析了年龄,BMI,季节和部署历史等因素,以确定它们与VDD的相关性.
- 参与者每天服用维生素D补充剂,并对包括维生素D水平,血清和心理症状在内的结果进行监测.
主要成果:
- 在没有补充剂的GWV中,VDD的流行率 (>90%) 平均水平低于正常范围.
- 虽然BMI与TBI组的VDD相关,但年龄,季节和人口统计数据在PTSD组中没有显著的相关性.
- 多次部署显示了与维生素D水平的轻微负面关联.
- 维生素D补充剂使维生素D水平正常化,而不会影响血清.
- 在大多数接受治疗的退伍军人中,观察到抑郁症,焦虑症,TBI和PTSD症状的显著解决.
结论:
- 纠正GWV的VDD与IBS-D和同时发生的PTSD/TBI有效地减少了心理症状.
- 维生素D补充提供了一种简单而有效的策略,用于管理这种人群中的神经心理疾病.
- 这种方法可以作为增加神经营养药物的替代或辅助.
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