在膀癌细胞系中探索多菌株益生菌配方OxxySlab的抗癌潜力
Valeria Ciummo1, Alessia Ciafarone2, Serena Altamura2
1Department of Innovative Technologies in Medicine and Dentistry, University "G. d'Annunzio", 66100 Chieti, Italy.
Antioxidants (Basel, Switzerland)
|November 27, 2025
概括
一种益生菌OxxySlab在膀癌 (BC) 治疗方面表现有前途. 它通过诱导衰老和抑制EMT,选择性地抑制BC细胞生长和迁移,同时节省正常细胞.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 细胞生物学 细胞生物学
背景情况:
- 膀癌 (BC),特别是肌肉侵入性BC (MIBC),具有重大临床挑战,复发率高,治疗选择有限.
- 益生菌正在研究选择性抗癌效应,可能保护健康组织.
研究的目的:
- 评估多种菌株益生菌配方OxxySlab对膀癌细胞的抗瘤潜力.
- 研究OxxySlab对癌细胞影响的机制及其对正常泌尿道细胞的选择性.
主要方法:
- 在T24和5637膀癌细胞系和SV-HUC1正常尿道细胞上测试OxxySlab溶解酸.
- 评估增殖,克隆性和迁移的抑制;评估上皮质-介质细胞过渡 (EMT),衰老和氧化还原均质.
- 通过与维生素C联合治疗来研究氧化应激的作用.
主要成果:
- 根据剂量,OxxySlab抑制了BC细胞的增殖,克隆原性和迁移,同时保留了正常的尿细胞.
- 该配方抑制了EMT,诱导衰老,并破坏了恶性细胞的氧化还原稳定,与氧化应激有关.
- 维生素C的联合治疗减少了ROS的积累和衰老,证实了氧化应激是关键的调解者.
结论:
- OxxySlab证明了针对膀癌细胞的选择性抗瘤作用.
- 益生菌通过氧化还原介导衰老和EMT抑制来降低瘤的攻击性.
- OxxySlab是一种潜在的膀癌辅助疗法,可以保持正常的尿路细胞功能.
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