从天然产品中发现药物的双重目标洞察力作为GLP-1的调节剂和代谢综合征中的TXNIP-胆素抗氧化系统
Peter Chinedu Agu1,2, Appolonia Fulgence Yudas1, Jun Lu1
1Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, China.
Antioxidants (Basel, Switzerland)
|November 27, 2025
概括
天然化合物为代谢综合征 (MetS) 提供了一个有前途的治疗途径,通过TXNIP-thioredoxin系统准氧化应激,并增强类似葡萄糖-1 (GLP-1) 信号通路. 这些多目标天然产品为打击MetS提供了一种新的方法.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢综合征 (MetS) 是一个日益严重的全球健康问题,其特点是相互关联的代谢异常.
- 类似葡萄糖类-1 (GLP-1) 是MetS的治疗标,但合成激动剂具有局限性.
- 氧化应激,由铁素相互作用蛋白 (TXNIP) /铁素系统介导,是MetS的一个关键的致病因素.
研究的目的:
- 为了检查可以同时准TXNIP-thioredoxin抗氧化轴和GLP-1信号传递的天然化合物.
- 探索这些化合物如何能够解决MTS中氧化和荷尔蒙失调的问题.
- 突出自然产品的潜力,开发多目标治疗的MetS.
主要方法:
- 对自然化合物影响TXNIP-thioredoxin和GLP-1通路的临床前证据的审查.
- 分析机制,包括TXNIP表达调节,硫素活性增强,GLP-1分泌刺激,DPP-4抑制和GLP-1受体激动.
- 探索用于优化的集成计算技术.
主要成果:
- 天然化合物可以限制TXNIP的表达,并增加硫素活性.
- 这些化合物刺激GLP-1分泌,抑制DPP-4,或作为GLP-1受体激动剂.
- 在GLP-1介导的TXNIP降低调节增强抗氧化剂防御和胰腺β细胞功能时,观察到协同效应.
结论:
- 天然产品提供了一个独特的机会,用于多目标治疗MetS.
- 克服生物可用性和稳定性等转化挑战至关重要.
- 计算方法可以加速开发基于天然产品的MetS疗法.
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