在早产新生儿中发病的富洛塞米德诱导的神经:对观察数据的批判性审查
John Dotis1, Alexandra Skarlatou2, Maria Fourikou1
1Third Department of Pediatrics, Aristotle University of Thessaloniki, Hippokration Hospital, 54642 Thessaloniki, Greece.
Children (Basel, Switzerland)
|November 27, 2025
概括
在早产婴儿中使用富罗塞米德与脏结症 (NC) 相关,这是一种脏问题. 证据表明剂量依赖的风险,但谨慎的管理可以减轻这种并发症.
科学领域:
- 新生儿医学 新生儿医学
- 儿科脏病学 儿科脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 富洛塞米德是早产新生儿的常见利尿剂.
- 甲 (NC) 是一种潜在的脏并发症,与furosemide相关.
- 西米德相关的NC的长期影响需要澄清.
研究的目的:
- 审查在早产婴儿中furosemide和NC之间的关联.
- 综合有关NC发生率,风险因素和结果的证据.
- 为了告知新生儿安全使用利尿剂.
主要方法:
- 对接受罗塞米德治疗的早产婴儿NC的观察性研究 (1982-2025) 的文献综述.
- 提取有关研究特征,NC流行率和富洛塞米德暴露的数据.
- 提取数据的描述性综合.
主要成果:
- 22项研究 (1489名婴儿) 显示NC的患病率在6-83%之间.
- 在怀孕32周以下的婴儿或1500克以下的婴儿中观察到更高的NC发生率.
- 在NC组中,累积的富罗塞米德剂量显著高于NC组 (10-19 mg/kg vs. ≤5 mg/kg),这表明了剂量与反应的关系.
- 在停止治疗后,NC解决发生在~60%的病例中.
- 最近的一项RCT表明,在谨慎使用罗西米德剂量 (≤2 mg/kg/天28天) 时,NC风险没有增加.
结论:
- 在早产婴儿中,furosemide和NC之间存在与剂量相关的关联.
- 谨慎的剂量和监测可能会减轻NC风险.
- 进一步的研究对于优化furosemide在新生儿中安全使用至关重要.
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