连续抗生素预防膀管外流症:对儿科微生物组的影响-一项系统性审查
Olivia Oana Stanciu1,2, Andreea Moga1,2, Laura Balanescu1,2
1Department of Pediatric Surgery and Orthopedics, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Children (Basel, Switzerland)
|November 27, 2025
概括
连续抗生素预防 (CAP) 对于患有膀外流的婴儿 (VUR) 保持了微生物多样性,但改变了肠道微生物群的组成,增加了抗菌素耐药性. 这凸显了除了预防感染外,还需要进行微生物群保护干预措施.
科学领域:
- 儿科脏病学 儿科脏病学
- 微生物组研究 微生物组研究
- 传染性疾病 传染性疾病
背景情况:
- 持续的抗生素预防 (CAP) 对于患有膀外流 (VUR) 的婴儿来说是标准的,以预防尿路感染 (UTIs) 和脏痕.
- 在婴儿期长时间接触抗生素可能会影响发育中的微生物群和免疫系统.
- CAP对婴儿微生物组的长期影响尚未完全理解.
研究的目的:
- 系统地审查CAP对VUR儿童肠道和尿道微生物群的影响.
- 评估与CAP相关的微生物组成,多样性和抗菌素耐药性的变化.
- 为平衡感染预防与婴儿微生物健康的策略提供信息.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 搜索了主要的数据库 (PubMed,Embase,Scopus,科学网,科克兰图书馆) 至2025年9月.
- 包括使用测序或培养方法评估接受CAP治疗VUR的儿童 (18岁以下) 微生物组变化的研究.
主要成果:
- 四项研究 (3项观察性,1项RCT) 符合纳入标准.
- CAP保持了整体的微生物α多样性,但丰富了Enterobacteriaceae和减少了Bifidobacteriaceae.
- 随机试验表明尿路感染复发减少,但抗菌素耐药性增加和非大肠杆菌感染.
结论:
- 婴儿CAP改变了微生物群组成和耐药性概况,尽管保留了多样性.
- 研究结果表明,早期暴露于抗生素的潜在长期生态影响.
- 需要个性化预防和微生物群保护干预措施来优化VUR管理.
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