儿科创伤性脑损伤后内分泌功能障碍:当前见解和未来方向
Ignazio Cammisa1, Elena Malavolta1, Giorgio Sodero2,3
1Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Children (Basel, Switzerland)
|November 27, 2025
概括
儿童创伤性脑损伤 (TBI) 可以导致长期的内分泌问题,影响生长和青春期. 定期监测对于早期检测和改善儿科患者的治疗结果至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经创伤是一种神经创伤.
- 儿童健康 儿童健康
背景情况:
- 儿童创伤性脑损伤 (TBI) 是一个日益严重的全球健康问题.
- 创伤后内分泌功能障碍是小儿TBI的一个未被认可的并发症.
- 脑下垂体轴 (HPA) 特别容易受伤害.
研究的目的:
- 审查儿科TBI后内分泌功能障碍的频谱和患病率.
- 突出这些功能障碍的长期后果.
- 强调结构化内分泌监测的必要性.
主要方法:
- 关于儿科TBI和内分泌结果研究的文献综述.
- 报告的患病率和类型的垂体功能障碍的分析.
- 讨论诊断挑战和管理策略.
主要成果:
- 脑下垂体功能障碍的患病率在TBI后为5%至57%.
- 生长激素缺乏 (GHD) 是最常见的异常.
- 其他问题包括淋巴腺,上腺和下垂体后部疾病,往往是延迟发病.
结论:
- 内分泌连续反应可能在TBI后多年表现出来,使诊断复杂化.
- 结构化,纵向内分泌监测对于小儿TBI幸存者至关重要.
- 早期识别和干预可以改善康复结果.
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