耐火性食品蛋白诱导过敏性肠道炎的临床特征分析
Juan Zhang1, Hui Wu1, Jun Li2
1Department of Pediatrics, Peking University of Third Hospital, Beijing 100191, China.
Children (Basel, Switzerland)
|November 27, 2025
概括
耐药性食物蛋白诱导过敏性直肠炎 (FPIAP) 经常持续,特别是在非早期发病的情况下. 这些患者经历了更多的生长问题,需要更多的皮质类固醇治疗.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 过敏 免疫学 免疫学
背景情况:
- 食物蛋白引起的过敏性肠道炎 (FPIAP) 是一种非IgE介导的过敏性肠道炎.
- 虽然大多数FPIAP病例在1岁时就会消失,但耐火病例可能导致缓解和增长迟缓.
- 了解耐火性FPIAP对于有效的儿科管理至关重要.
研究的目的:
- 研究患有耐火性FPIAP的儿科患者的临床特征,治疗策略和结果.
- 为了比较早期发病与非早期发病的耐火性FPIAP.
- 确定与疾病严重程度和治疗反应相关的因素.
主要方法:
- 35名患有耐火性FPIAP的儿科患者的回顾性分析 (2015年1月至2025年1月).
- 根据症状发作,患者被分为早期发病和非早期发病组.
- 收集和分析了临床数据和治疗方案.
主要成果:
- 非早期发病的FPIAP显示出显著更高的增长迟缓比例 (73.3%与35.0%) 和较低的血红蛋白水平 (107.93 ± 14.61 g/L与118.95 ± 11.26 g/L).
- 在早期发病组中,皮质类固醇的使用明显较低 (15.0%vs. 60.0%).
- 在随访期间,40%的患者患有持续的食物不耐受,包括牛奶,蛋和小麦.
结论:
- 耐火性FPIAP是一种长期的疾病,基于发病时间的不同特征.
- 非早期发病的FPIAP与增长迟缓,降低血红蛋白和更高的皮质类固醇需求有关.
- 需要进一步的研究来确定耐火性FPIAP的最佳治疗策略.
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