9岁男孩患有动脉瘤骨囊的严重反弹高热血病对登诺苏马布的显著反应:一个病例报告
Laurence Allain1, Sarah Elbaz1, Sayanthen Sathyakumar1
1Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada.
Children (Basel, Switzerland)
|November 27, 2025
概括
德诺苏马布有效地减少了儿童的大型动脉瘤骨囊. 然而,停止这种治疗导致高血症和急性损伤,需要仔细监测潜在的副作用.
科学领域:
- 儿科瘤学 儿科瘤学
- 口腔和牙面部外科手术
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 动脉瘤骨囊 (ABC) 是一种罕见的良性骨瘤,通常发生在儿童的骨中.
- 大型ABC可以导致显著的发病率,包括面部形和功能障碍.
- 目前对下腹ABC的治疗选择可能是侵入性的,可能有局限性.
研究的目的:
- 报道了一例成功的非标签denosumab治疗一个大下动脉瘤骨囊在一个儿科患者的病例.
- 要突出在停止使用登苏马布后可能出现反弹性高血症和急性损伤的可能性.
- 讨论denosumab在管理ABC中的风险-益处概况.
主要方法:
- 一个9岁的男孩有一个大下ABC被治疗了denosumab17个月.
- 监测了患者对治疗的反应和随后不良事件的发展.
- 记录了并发症的管理,包括高血症和急性损伤.
主要成果:
- 德诺苏马布治疗导致动脉瘤骨囊大小显著减少.
- 停用德诺苏马布导致严重的反弹高血症和急性损伤.
- 这些并发症成功地用皮质类固醇治疗,治疗后囊的尺寸继续减少.
结论:
- 德诺苏马布证明了作为小儿下巴动脉瘤骨囊的非标签治疗的有效性.
- 临床医生必须警可能发生的严重不良事件,特别是高血症和急性损伤,在denosumab停止后.
- 在ABC中,应根据个体情况做出denosumab治疗决定,并密切监测患者的疗效和安全性.
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