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在接受bDMARDs的儿童中对疫苗的抗体反应的初步病例对照研究

Asuman Demirbuğa¹, Elif Dede², Deniz Bahar Akgün Karapınar³

¹Pediatric Infectious Diseases, Mardin Training and Research Hospital, 47100 Mardin, Türkiye.

Children (Basel, Switzerland)

|November 27, 2025

概括

接受生物治疗的患者对乙型肝炎,肺炎球菌和麻疹的疫苗反应充足. 然而,对于那些水平下降的人来说,监测抗体标位至关重要,以确保对疫苗可预防的疾病的保护.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
疫苗学疫苗学疫苗学

背景情况:

接受生物修饰性抗风湿药物 (bDMARD) 治疗的类风湿病患者面临感染风险增加.
疫苗接种对于预防这种脆弱人群感染至关重要.

研究的目的:

评估接受bDMARD治疗的儿科患者对乙型肝炎,肺炎球菌和麻疹的疫苗反应.
为了比较bDMARDs和健康对照患者之间的抗体标位.

主要方法:

一项病例控制研究,涉及16名接受bDMARDs的患者 (5-18岁) 和20名健康对照.
血清IgG抗体标位 (抗HBsAg,抗PCP,抗麻疹) 测量在基线,3个月和bDMARD开始后6个月.
两组之间的抗体标位和随着时间的推移的比较.

主要成果:

患者和对照组之间平均抗体标位 (抗HBsAg,抗PCP,抗麻疹) 没有显著差异.
保护性抗体的百分比:抗HBsAg (68.8%),抗PCP (100%),抗麻疹 (56.25%).
在6个月前,在少数患者中观察到抗麻疹标位的最小下降.

结论:

接受bDMARDs的患者通常保持足够的疫苗诱导抗体水平.
建议在bDMARD治疗期间对乙型肝炎和麻疹抗体标位进行密切监测,对于在bDMARD治疗期间水平低或下降的患者.
定期查和随访对于确保在这个群体中保护免受疫苗预防的疾病至关重要.

关键词:

这是一种抗HbsAg的药物.这是一种抗PCP药物.抗麻疹药物IgGG 抗麻疹药物 bDMARDARD 的意思是什么儿科类风湿性疾病儿童类风湿性疾病

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