在儿科慢性异常性便秘中,先发症水液与肉毒毒素对比:在单一中心进行10年后期研究
Prisca C Obidike1, Trevor C Jones1, Chioma Moneme1
1Department of Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Children (Basel, Switzerland)
|November 27, 2025
概括
预发性失禁阴囊 (ACE) 和肉毒素 (BT) 注射改善了儿科便秘症状,并减少了药的使用. 与BT相比,ACE显示药使用减少更大,但医疗保健访问增加.
科学领域:
- 儿科手术 儿科手术
- 儿科胃肠病学 儿科胃肠病学
- 结肠直肠手术 结肠直肠手术
背景情况:
- 慢性异常性便秘 (CIC) 是一种流行的儿科胃肠道疾病,需要对耐火病例进行干预.
- 对于严重的CIC,可以考虑使用手术选择,如前级失禁阴囊 (ACE) 和肉毒素 (BT) 注射.
- 评估ACE和BT的比较有效性对于优化治疗策略至关重要.
研究的目的:
- 为了比较ACE和BT注射对儿科CIC患者的药使用的影响.
- 评估便秘相关症状的解决和手术后的医疗保健利用情况.
- 确定这些手术干预的长期疗效和资源利用率.
主要方法:
- 对被诊断患有CIC和便失禁 (罗马IV标准) 的儿科患者 (≤18岁) 进行了回顾性图表审查.
- 包括接受ACE通道创建或BT内部关节注射的患者.
- 测量结果包括每日口服药使用的变化,症状缓解 (压缩,腹痛,膨胀),以及术后1年的医疗保健访问.
主要成果:
- 在125名儿科CIC患者中,47.6%进行了手术,其中36.2%接受了ACE,63.8%接受了BT.
- 在这两组中,每日药的使用量都显著下降,在ACE组中观察到的减少更大 (41.0%与60.2%相比).
- 在两组中,压,腹痛和张张的症状解决在两组中都是显著的,没有跨组差异. 在ACE患者中,术后门诊次数较多,而在BT患者中则较少.
结论:
- 无论是ACE和BT干预措施都显著改善了便秘症状,并减少了儿科患者对药的依赖.
- 与BT相比,ACE显示出每日药需求的优越减少.
- 虽然ACE有效,但与术后医疗保健利用率的增加有关,需要仔细选择和管理患者.
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