儿童复发性尿道感染中的抗生素耐药性趋势:一个为期五年的单中心经验
Olivia-Oana Stanciu1,2, Mircea Andriescu1,2, Andreea Moga1,2
1Department of Paediatric Surgery and Orthopaedics, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Children (Basel, Switzerland)
|November 27, 2025
概括
儿科复发性尿路感染 (rUTIs) 的多药性耐药性 (MDR) 和扩展谱β-乳糖酶 (ESBL) 率高但稳定. 持续的监测和管理对于保持儿童抗生素有效性至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 临床微生物学 临床微生物学
- 抗微生物药物管理委员会
背景情况:
- 儿童的反复性尿路感染 (rUTIs) 由于抗菌素耐药性增加而带来挑战.
- 治疗选择有限,预防管理困难,需要对局部抗药性进行监测.
- 基于证据的抗微生物药物管理需要持续监测耐药性趋势.
研究的目的:
- 分析多药性耐药性 (MDR) 和扩展光谱β-乳糖酶 (ESBL) 生产生物体在儿科RUTIs中的趋势.
- 为了确定与MDR相关的临床因素,在儿童与RUTIs.
- 评估MDR和ESBL利率在五年时间内的时间稳定性.
主要方法:
- 用ICD-10代码N39.0.0.0进行儿科rUTI病例 (2020-2024) 的回顾性分析.
- 包括人口,临床和微生物学数据,以及抗菌素敏感性测试.
- 包括后勤回归和Cochran-Armitage趋势测试在内的统计分析,以评估MDR预测因素和时间趋势.
主要成果:
- 在48.5%的分离物体中观察到多药性耐药性 (MDR),在20.9%的分离物体中观察到ESBL产生.
- MDR与尿路形和持续抗生素预防有显著的关联.
- 在研究期间,没有发现MDR率的显著时间增加.
结论:
- 儿科RUTIs中的MDR和ESBL率仍然很高,但已经稳定下来.
- 该研究证实,阻力没有显著上升趋势.
- 持续的监测和管理对于保持小儿rUTI管理中的抗生素疗效至关重要.
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