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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

72.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.4K
Alternative RNA Splicing02:18

Alternative RNA Splicing

24.6K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.6K

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相关实验视频

Updated: Jan 10, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

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多发性硬化症中的长非编码RNA - 差异表达和功能影响

Kaalindi Misra1, Aishwary Nerkar1, Ferdinando Clarelli1

  • 1Laboratory of Human Genetics of Neurological Disorders, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Genes
|November 27, 2025
PubMed
概括
此摘要是机器生成的。

长非编码RNAs (lncRNAs) 在多发性硬化症 (MS) 中显示出一致但特定于背景的变化. 本次审查强调了关键的lncRNA和途径,呼吁进行标准化研究,以推进诊断和治疗.

关键词:
在CNS中,CNS是CNS.在MSMSMSMSMSMSMSMSMSMSMS中,我们可以看到在RRMS中使用RRMS.这就是SPMS的意义.在ncRNA中,我们可以

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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相关实验视频

Last Updated: Jan 10, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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科学领域:

  • 免疫基因组学是什么
  • 分子生物学分子生物学
  • 神经免疫学 神经免疫学

背景情况:

  • 长非编码RNAs (lncRNAs) 是免疫反应的新兴调节者.
  • 在多发性硬化症 (MS) 等自身免疫性疾病中,lncRNAs可能具有诊断和治疗潜力.
  • 现有的关于多发性硬化症中 lncRNAs 的研究是分散的,并且在地理上有限.

研究的目的:

  • 系统地审查和评价有关MS中lncRNA表达的研究.
  • 评估不同研究中的发现的一致性.
  • 合成MS中经常研究的lncRNAs的功能作用.

主要方法:

  • 使用PRISMA指南对51项研究 (2010-2024) 的系统审查.
  • 搜索了主要的数据库 (PubMed,Scopus,Embase,Web of Science) 进行了搜索.
  • 包括20名以上成年多发性硬化症患者的研究,通过qRT-PCR,RNA-seq或微阵列分析生物样本中的lncRNA.

主要成果:

  • 确定了77个独特的lncRNAs,其中MALAT1,GAS5,MEG3和H19在MS中显示出一致的失调.
  • 其他lncRNAs (例如,THRIL,IFNG-AS1) 显示了取决于上下文的表达.
  • 功能分析涉及NF-κB,STAT3和IFN-γ/Th1信号传递等途径.

结论:

  • 在MS中显而易见的可复制和特定于背景的lncRNA失调.
  • 强调需要进行全转录组研究,标准化方法和多中心验证.
  • 目前的研究局限性包括地理偏差,预选择偏差和方法异质.