乳腺细胞激活在肌痛性脑筋炎/慢性疲劳综合征的临床相关性
Johanna Rohrhofer1, Lilian Ebner1, Johannes Schweighardt1
1Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
巨细胞激活 (MCA) 在肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 中很常见,并与静态不耐受性 (OI) 相关. 向巨细胞可能会改善MCA和OI的ME/CFS患者的症状.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 内部医学 内部医学
背景情况:
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 是一种复杂的疾病,经常伴随着衰弱的疲劳和运动后的不适 (PEM).
- 越来越多的证据表明,巨细胞激活 (MCA) 和ME/CFS的病理生理学之间存在潜在的联系,特别是关于静态不耐受 (OI).
研究的目的:
- 调查在奥地利一组被诊断患有ME/CFS的患者中瘤细胞激活 (MCA) 的患病率和临床意义.
- 探索MCA,OI (包括POTS) 和ME/CFS患者治疗反应之间的关联.
主要方法:
- 分析了两个数据集:用于患者分层的大型在线问卷 (CCCFS,687项调查) 和重点关注MCA和OI的回顾性研究 (383名患者).
- 评估与MCA状态有关的自我报告的临床特征,疾病进展和对各种治疗的反应.
主要成果:
- 临床相关的MCA在多达25.3%的ME/CFS患者中被发现,其患病率在疾病过程中增加.
- 患有乳腺细胞激活综合征 (MCAS) 和OI的ME/CFS患者在瘤细胞向治疗时,与没有MCAS的患者相比,症状缓解明显更好.
- 在两个队列中,OI,特别是POTS在ME/CFS患者中显著更为普遍,MCA参与.
结论:
- 巨细胞激活 (MCA) 是ME/CFS中常见且临床相关的并发症,与OI,特别是POTS的更高发病率密切相关.
- 根据MCA状态对ME/CFS患者进行分层可能有助于个性化治疗策略,并提高临床结果.
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