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CCD抑制对半定量性多重过敏原同时测试的影响

Hyeyoung Lee¹, Kyungcheol Song¹, Jiwoo Kim¹

¹Department of Laboratory Medicine, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 22711, Republic of Korea.

Diagnostics (Basel, Switzerland)

|November 27, 2025

概括

交叉反应性碳水化合物决定因素 (CCD) 在过敏测试中引起假阳性. 抑制CCD显著减少了多种过敏原同时测试 (MAST) 中的假阳性,提高了对食物和花粉过敏的准确性.

科学领域:

过敏和免疫学过敏和免疫学
诊断测试诊断测试诊断测试
生物化学生物化学

背景情况:

众所周知,交叉反应性碳水化合物决定剂 (CCD) 在过敏原特定的IgE测定中会导致假阳性结果.
这可能导致过度估计过敏症,使得精确的过敏诊断变得复杂.

研究的目的:

评估CCD抑制对半定量多重过敏原同时测试 (MAST) 的影响.
评估CCD阻断剂在减少假阳性IgE结果中的有效性.

主要方法:

分析了65个用抗CCDIgE的血清样本.
在CCD阻断剂预处理之前和之后,对6624种过敏原特异性IgE结果进行比较.
用不同度的CCD阻断剂进行剂量反应分析.

主要成果:

抑制CCD将64.1%的阳性IgE结果转化为阴性.
对于食物 (28.2%至8.1%) 和花粉 (70.1%至23.3%) 的过敏原,观察到IgE阳性的显著降低.
像蜜蜂和黄色克这样的毒素过敏原显示出显著的IgE水平下降,在94.1%的病例中解决了双阳性.

结论:

通过减少假阳性结果,CCD抑制显著提高了MAST的特异性.
这些发现强调了CCD阻断对于准确诊断的重要性,特别是对于食物和花粉过敏.

关键词:

这就是为什么CCD是CCD,CCD是CCD.在 IgE 中,IgE 是过敏原过敏原过敏原

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