在缺血性中风中沿周血管空间 (DTI-ALPS) 进行扩散张力成像:对中风后认知障碍的诊断和预后性能进行系统审查
Mirela Loredana Grigoras1, Andrei-Cristian Bondar2, Felix Bratosin3
1Department of Functional Sciences, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Diagnostics (Basel, Switzerland)
|November 27, 2025
概括
随着周血管空间 (DTI-ALPS) 的扩散张力成像分析显示,中风后扩散性降低,与认知功能相关,并预测结果. 需要标准化的DTI-ALPS方法用于临床治疗中风后认知障碍.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 脑卒中后认知障碍 (PSCI) 影响大约40%的中风幸存者.
- 周周血管空间的扩散张力成像分析 (DTI-ALPS) 提供了一种无对比的方法来评估周周血管扩散性,可能有助于PSCI风险分层.
研究的目的:
- 系统地审查DTI-ALPS在缺血性中风患者的诊断和预后性能.
- 综合关于DTI-ALPS与中风后认知和功能结果之间的关联的证据.
主要方法:
- 在PubMed/MEDLINE,Scopus和Web of Science (开始至2025年8月) 的系统文献搜索.
- 包括报告DTI-ALPS和缺血性中风的认知/功能结果的队列和病例控制研究.
- 使用QUADAS-2和QUIPS进行偏差风险评估;异质性排除了元分析.
主要成果:
- 五个单中心队列 (n=29-120) 使用3T DTI与心室ALPSROIs.
- DTI-ALPS在中风后持续较低,显示部分恢复,与MoCA得分相关 (r ≈ 0.43-0.56),并歧视早期认知障碍 (AUC 0.868).
- 随访DTI-ALPS预测了6个月的不良结果 (AUC0.786);较高的基线ALPS在缺口性中风与更好的认知轨迹相关.
结论:
- DTI-ALPS显示,中风后持续减少和恢复敏感的变化.
- 图像技术显示出对PSCI和长期结果的有希望的,尽管取决于背景的预后价值.
- 临床翻译需要标准化的获取,分析,多式调整和多中心验证.
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