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败血症中的互白素网络:从细胞因子风暴到临床应用
Marcello Candelli1,2, Marta Sacco Fernandez2, Gloria Rozzi2
1Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Diagnostics (Basel, Switzerland)
|November 27, 2025
概括
互白蛋白 (ILs) 是败血症的关键参与者,驱动有害的炎症和免疫抑制. 了解它们的双重作用对于开发败血症生物标志物和个性化疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 病理生理学 病理生理学
背景情况:
- 败血症是一种危及生命的疾病,是由宿主对感染的反应失调引起的,导致器官功能障碍.
- 互白蛋白 (ILs) 是败血症发病的中心调解者,影响着保护性和有害性免疫反应.
- 涉及ILs的细胞因子风暴是败血症的标志,对发病率和死亡率做出了重大贡献.
研究的目的:
- 审查当前关于互白蛋白 (ILs) 在败血症病理生理学的作用的知识.
- 突出ILs作为败血症诊断/预后生物标志物的潜力.
- 在败血症管理中探索针对IL途径的治疗策略.
主要方法:
- 对毒中关键ILs (IL-1,IL-6,IL-10,IL-8,IL-12,IL-18,IL-17) 的最近临床和实验研究的分析.
- 专注于机械洞察力,预后意义和治疗干预措施.
- 评估ILs在免疫反应,炎症和器官功能障碍中的参与.
主要成果:
- IL-1和IL-6是强大的促炎媒介;IL-6是经过验证的预后生物标志物.
- IL-10作为一种抗炎细胞因子,但可以导致免疫抑制和二次感染.
- 其他ILs (IL-8,IL-12,IL-18,IL-17) 有助于中性粒细胞的招募,免疫细胞的激活和器官损伤.
- 向疗法 (例如,IL-1受体抗剂,IL-6受体阻断) 在特定的败血症患者群体中表现有前途.
结论:
- 互白蛋白在败血症免疫病理学中发挥着关键的双重作用,调解过度炎症和免疫抑制.
- ILs是有价值的诊断和预后生物标志物,以及取决于背景的治疗点.
- 精确免疫调节和个性化医疗对于改善败血症结果至关重要.
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