桥梁发现和治疗:癌症生物标志物
Hengrui Liu1, Ilayda Karsidag2, Rebecca Golin3
1Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.
Cancers
|November 27, 2025
概括
生物标志物正在通过实现个性化治疗来彻底改变癌症护理. 本综述涵盖了检测方法,转化挑战和人工智能驱动的解决方案,以改善患者的治疗结果并克服瘤异质性.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 个性化医疗是个性化的医疗.
背景情况:
- 生物标志物通过将分子信息与量身定制的治疗方法连接起来,显著提升了癌症护理.
- 多种检测方式的整合对于全面的癌症分析至关重要.
研究的目的:
- 审查当前癌症生物标志物检测模式的情况.
- 批判性地评估阻碍生物标志物的临床实施的挑战.
- 探索生物标志物开发和应用的新兴解决方案和未来方向.
主要方法:
- 关于生物标志物检测技术的综合文献综述.
- 分析临床实施中的翻译挑战.
- 探索新兴技术和未来的研究方向.
主要成果:
- 存在广泛的检测方式,包括组织基因组学,液体活检 (ctDNA,CTC,细胞外囊泡),成像/放射学和多组学.
- 显著的翻译挑战阻碍了临床使用,例如测试标准化,数据集成,验证,监管障碍和成本.
- 新兴的解决方案,如人工智能驱动的表型化,适应性试验和临床检测,显示出有希望的结果.
结论:
- 生物标志物在指导向性和基于免疫的治疗中起着关键作用.
- 解决转化挑战和利用新技术可以克服瘤异质性和耐药性.
- 扩大获取和公平采用生物标志物导向的癌症护理对于改善患者的治疗结果至关重要.
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