相关实验视频
Updated: Jan 10, 2026

10:42
A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
10.0K
在嗅觉刺激期间血管痴呆症中改变前额前部动态功能连接:一项fNIRS研究
Sungchul Kim1, Seonghyun Kim2, Seung Ha Hwang3
1Institute for Artificial Intelligence, N.CER, Gwangju 61005, Republic of Korea.
Bioengineering (Basel, Switzerland)
|November 27, 2025
概括
功能近红外光谱学 (fNIRS) 在嗅觉刺激期间在血管痴呆症 (VD) 患者中揭示了改变的大脑网络动态. 动态功能连接 (dFC) 显示了静脉疾病的显著波动,表明了潜在的静脉疾病的非侵入性生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 神经学 神经学
背景情况:
- 血管痴呆症 (VD) 是一种渐进性的认知障碍.
- 了解静脉疾病中大脑网络的改变对于诊断和治疗至关重要.
- 嗅觉功能障碍通常是神经退行性疾病的早期迹象.
研究的目的:
- 为了研究动态功能连接 (dFC) 变化,以响应VD患者的嗅觉刺激.
- 为了比较健康对照组和静脉疾病患者之间的dFC反应.
- 探索fNIRS作为一种非侵入性工具的潜力,用于评估VD中的大脑功能.
主要方法:
- 功能近红外光谱学 (fNIRS) 用于测量大脑活动.
- 动态功能连接 (dFC) 估计使用一个移动窗口相关性方法.
- 参与者经历了休息和嗅觉刺激的周期.
主要成果:
- 与健康对照组相比,VD组在氧和脱氧血球dFC中表现出更广泛的波动.
- 在嗅觉刺激期间,在组之间观察到dFC的显著差异.
- 这些差异具有中等到大的效果大小.
结论:
- 嗅觉唤起的dFC变化可能表明静脉疾病中大脑网络动态受损.
- 基于fNIRS的dFC分析显示出作为一种非侵入性和可访问的工具来理解VD的承诺.
- 需要进一步的研究来验证这些发现,并探索临床应用.
相关概念视频
Olfaction
48.0K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
48.0K
Olfactory Receptors: Location and Structure
11.1K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.1K

