创伤治愈中的智能生物材料:智能包装设计的进步,挑战和未来方向
Yanlin Liu1, Liqin Ge1,2
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Bioengineering (Basel, Switzerland)
|November 27, 2025
概括
智能伤口包裹积极监测和响应慢性伤口,提供个性化的治疗方法. 这些先进的系统旨在改善治疗结果,并减少患有糖尿病足等疾病的患者的并发症.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 再生医学是一种再生医学.
背景情况:
- 慢性伤口,包括糖尿病足和压力,带来了重大的临床挑战和相当大的经济负担.
- 持续的炎症,感染风险和组织再生不良阻碍了慢性伤口的愈合.
- 目前的伤口护理依赖于被动带,强调了对先进治疗解决方案的需求.
研究的目的:
- 审查智能伤口包裹的景观,专注于其生物工程设计和响应功能.
- 讨论这些先进带在治疗慢性伤口和改善患者治疗结果方面的潜力.
- 确定智能伤口技术临床转化的主要挑战和未来方向.
主要方法:
- 关于智能伤口包裹技术的最新文献的全面审查.
- 根据传感和响应机制 (pH,温度,湿度,压力,电气,生物传感,形状记忆,药物释放) 进行包装的分类.
- 分析与临床实施相关的挑战,包括生物相容性,稳定性,可扩展性,成本和监管批准.
主要成果:
- 智能伤口带为伤口微环境提供动态监测和响应能力.
- 目前正在开发各种响应系统,包括pH敏感,温度敏感,湿度敏感,压力感应,电活性,生物传感器集成,形状记忆和控制药物释放的包裹.
- 临床转化仍然存在重大障碍,包括生物相容性,长期稳定性,制造,成本,患者遵守和监管流程.
结论:
- 智能伤口代表了慢性伤口管理的范式转变,朝着个性化和持续治疗的方向前进.
- 这些先进的系统有潜力显著增强愈合,减少并发症,改善患者的生活质量.
- 克服转化挑战对于实现智能伤口包装技术的全部临床潜力至关重要.
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