D-阿斯巴酸对由聚乙烯微塑料诱导的丸损伤的保护作用和潜在机制
Sara Falvo1, Giulia Grillo1, Imed Messaoudi2
1Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania 'Luigi Vanvitelli', Via Vivaldi, 43, 81100 Caserta, Italy.
Biomolecules
|November 27, 2025
概括
D-阿斯巴酸 (D-Asp) 保护丸免受聚烯微塑料 (PS-MPs) 造成的丸损伤. D-Asp治疗逆转了PS-MP诱导的氧化应激,亡和自,改善了男性生殖健康.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 生物化学 生物化学
背景情况:
- 聚乙烯微塑料 (PS-MPs) 暴露与丸功能障碍有关,包括氧化应激,亡以及降低类固醇生成和精子生成.
- 众所周知,D-酸盐 (D-Asp) 刺激的生物合成和精子生成,并具有抗氧化和抗丧性质.
研究的目的:
- 在体内调查D-酸盐 (D-Asp) 对PS-MPs诱导的丸损伤的保护作用.
- 阐明D-Asp对PS-MP毒性的保护作用背后的机制.
主要方法:
- 成年大鼠接触到PS-MPs,其中一些接受了D-Asp治疗.
- 对丸氧化应激标志物 (CAT,SOD1,SOD2,4-HNE,TBARS) 的评估.
- 对亡 (CYT C,TUNEL测定) 和自的评估 (LC3BI,LC3BII,p62).
- 对类固醇原性 (StAR,3β-HSD,17β-HSD) 和精子原性 (PCNA,SYCP3) 标记物的分析.
主要成果:
- D-Asp治疗逆转了PS-MP诱导的氧化应激和亡的增加.
- D-Asp减轻了PS-MP诱导的自活化.
- D-Asp恢复了关键的类固醇和精子生成标记物的正常水平,抵消了PS-MP的损伤.
结论:
- 在大鼠中,D-阿斯巴甜酸对PS-微塑料诱导的丸损伤具有显著的保护作用.
- D-Asp通过抑制氧化应激,亡和自,并恢复类固醇生成和精子生成来改善丸功能障碍.
- 这些发现表明D-Asp对受微塑料污染影响的男性生殖健康的潜在治疗价值.
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