SMAnalyst:用于空间代谢数据分析和注释的Web服务器
Zhanlong Mei1, Xiaolian Ning2, Haoke Deng1
1BGI Genomics, Shenzhen 518083, China.
Biomolecules
|November 27, 2025
概括
SMAnalyst是一个新的开源平台,简化了空间代谢学分析. 它集成了质量控制,代谢物识别和差异分析,使复杂的数据可访问.
科学领域:
- *空间代谢学及其在理解组织代谢异质性方面的作用.
背景情况:
- *目前的空间代谢学分析受到碎片化的工具和缺乏集成的,开源的GUI软件的阻碍.
- * 缺少一个全面的工作流程,包括质量控制,预处理,识别,模式和差异分析.
研究的目的:
- * 开发SMAnalyst,一个集成的,开源的,基于Web的空间代谢学数据分析平台.
- * 提供一个用户友好的GUI,降低复杂的空间代谢学工作流程的进入障碍.
主要方法:
- * 开发一个整合平台,巩固多维数据质量评估.
- * 实施基于质量准确性,同位素相似性和引证证据的代谢物注释评分系统.
- *包括二维空间模式发现 (代谢物联合表达,像素聚类) 和灵活的差异分析.
主要成果:
- *SMAnalyst提供了一个统一的解决方案,消除了对工具切换和高级计算技能的需求.
- * 该平台在小鼠大脑数据集上成功测试,有效处理大规模数据 (>14,000像素,>3000离子峰值).
- * 在多维数据质量评估,代谢物注释和空间模式发现方面表现出能力.
结论:
- *SMAnalyst有效地解决了空间代谢学综合分析解决方案的关键缺口.
- * 该平台显著降低了分析障碍,促进了空间代谢学更广泛的采用.
- * 提供了一个全面的,用户友好的工具来分析生物组织中的代谢异质性.
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