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Updated: Jul 27, 2026

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
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分子动力学研究α-同核素域删除突变单体的研究

Noriyo Onishi1, Nicodemo Mazzaferro1, Špela Kunstelj1

  • 1Department of Chemistry, St. John's University, Queens, NY 11439, USA.

Biomolecules
|November 27, 2025
PubMed
概括

错误折叠的α-synuclein (aSyn) 蛋白质聚合是帕金森病的核心. 了解aSyn的域如何相互作用,揭示了其结构如何影响聚合和膜相互作用,为疾病机制提供了洞察力.

关键词:
跨领域的联系.本质上是无序的蛋白质.分子动力学分子动力学一个单质的单质分子.α-synuclein 是一种同核蛋白.

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